Monoclonal Antibody to Peripheral Myelin Protein 22 (PMP22)
Antibody Type
Primary Antibodies
Immunogen
Recombinant PMP22 (Met1~Glu160) expressed in E.coli.
Key Feature
Clonality
Monoclonal
Isotype
IgG2a,k
Host Species
Mouse
Tested Applications
WB
WB:0.5-5ug/mL IHC:5-30ug/mL ICC/IF:5-30ug/mL
Species Reactivity
Human
Concentration
1mg/ml
Purification
Protein A/G
Target Information
Gene Symbol
PMP22
Gene Synonyms
DSS CIDP GAS3 HNPP CMT1A CMT1E GAS-3 Sp110 HMSNIA
Gene Full Name
peripheral myelin protein 22
Gene Summary
his gene encodes an integral membrane protein that is a major component of myelin in the peripheral nervous system. Studies suggest two alternately used promoters drive tissue-specific expression. Various mutations of this gene are causes of Charcot-Marie-Tooth disease Type IA, Dejerine-Sottas syndrome, and hereditary neuropathy with liability to pressure palsies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]