A synthetic peptide of human Prostaglandin D Synthase.
Key Feature
Clonality
Monoclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
ICC/IFIHCWB
WB:1:1000 IHC:1:20 ICC/IF:1:20
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Symbol
PTGDS
Gene Synonyms
PDS PGD2 PGDS LPGDS PGDS2 L-PGDS
Gene Full Name
prostaglandin D2 synthase
Gene Summary
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]