IP-MS
The Motif Logo was generated from IP-MS experiment using 5000+ nonredundant tryptic peptides derved from mouse liver tissue immunoprecipitated with antibody. The logo represents the relative frequency of amino acids in each position surrounding the central Succinyllysine residue within this data set.| Product Name | Affinity Gel-conjugated Pan Succinyl-Lysine Rabbit mAb |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide. |
| Conjugation | Affinity Gel |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IP-MS |
| IP-MS:40 μL antibody (bead slurry) for 200μg-400μg extracts of whole cell |
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| Species Reactivity | All |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Target Description | The lysine residue in proteins can undergo to many types of PTMs, such as methylation, acetylation, biotinylation, ubiquitination, ubiquitin-like modifications,propionylation and butyrylation, then leading to the remarkable complexity of PTM networks. Succinylation is a posttranslational modification (PTM) where a succinyl group is added to a Lys (K) residue of a protein molecule .it has been shown that the lysine succinylation responses to different physiological conditions and is evolutional conserved. It has been identified 2,565 succinylation sites from 779 proteins and revealed that lysine succinylation have potential impacts on enzymes involved in mitochondrial metabolism including the amino acid degradation, tricarboxylic acid (TCA) cycle and fatty acid metabolism Thelysine succinylation also occurs in histones, suggesting that it may play an important role in regulating chromatin structures and functions as well |
|---|
IP-MS
The Motif Logo was generated from IP-MS experiment using 5000+ nonredundant tryptic peptides derved from mouse liver tissue immunoprecipitated with antibody. The logo represents the relative frequency of amino acids in each position surrounding the central Succinyllysine residue within this data set.| Application Notes | IP-MS:40 μL antibody (bead slurry) for 200μg-400μg extracts of whole cell |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage Buffer | Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
