IHC
Immunohistochemistry analysis of paraffin embedded Rat pancreas tissue using GLP-1 Rabbit mAb at a dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining.IHC
Immunohistochemistry analysis of paraffin embedded Mouse pancreas tissue using GLP-1 Rabbit mAb at a dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining.IF-P
Immunofluorescence analysis of paraffin embedded Rat pancreas using GLP-1 Rabbit mAb at a a dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining. High pressure antigen retrieval performed with 0.01M Citrate Buffer(pH 6.0) prior to IF staining.IF-P
Immunofluorescence analysis of paraffin embedded Mouse pancreas using GLP-1 Rabbit mAb at a a dilution of 1:100 (40x lens). Secondary antibody: Cy3 conjugated Goat anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining. High pressure antigen retrieval performed with 0.01M Citrate Buffer(pH 6.0) prior to IF staining.| Product Name | GLP-1 Rabbit mAb |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide. This information is considered to be commercially sensitive. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IF-PIHC |
| IHC:1:50-1:200 IF-P:1:50-1:200 |
|
| Species Reactivity | MouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | GCG |
|---|---|
| Gene Synonyms | GLP1 GLP2 GRPP GLP-1 |
| Gene Full Name | glucagon |
| Gene Summary | The protein encoded by this gene is a proglucagon precursor that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis in the liver. In addition, glucagon promotes lipolysis and ketone body formation during prolonged fasting or stress. Glucagon secretion is stimulated by low blood glucose and inhibited by high glucose or insulin. Glucagon is a ligand for a specific G-protein linked receptor called glucagon receptor, which activates the Gs protein-adenylate cyclase-cAMP-protein kinase A signaling pathway to regulate carbohydrate and lipid metabolism. Two of the other peptides, glucagon-like peptide-1 and glucagon-like peptide-2, are produced by the intestinal L-cells and secreted in response to nutrient ingestion, where they function as important regulators of glucose metabolism and intestinal physiology. Glucagon-like peptide-1 enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes satiety, making it a key incretin hormone for maintaining postprandial glucose levels. Glucagon-like peptide-2 primarily acts on the gut, promoting intestinal growth, enhancing nutrient absorption, and supporting mucosal integrity. Both peptides exert their effects through specific G-protein-coupled receptors, glucagon-like peptide-1 receptor and glucagon-like peptide-2 receptor, respectively, and analogs of glucagon-like peptide-1 are used clinically for the treatment of type 2 diabetes and obesity. The fourth peptide is similar to glicentin, an active enteroglucagon produced in the intestinal L-cells. This peptide is thought to have multiple roles in gastrointestinal physiology, including stimulating intestinal growth, modulating gut motility, and influencing the secretion of other gut hormones. Although its precise functions are less well-characterized than those of glucagon, glucagon-like peptide-1, or glucagon-like peptide-2, glicentin-like peptides may contribute to postprandial digestive processes and the coordination of nutrient absorption. [provided by RefSeq, Mar 2026] |
| Alternative Names | GLP1 GLP2 GRPP GLP-1 |
| Molecular Weight(MW) | 21 kDa |
| Cellular Localization | Secreted. |
IHC
Immunohistochemistry analysis of paraffin embedded Rat pancreas tissue using GLP-1 Rabbit mAb at a dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining.
IHC
Immunohistochemistry analysis of paraffin embedded Mouse pancreas tissue using GLP-1 Rabbit mAb at a dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining.
IF-P
Immunofluorescence analysis of paraffin embedded Rat pancreas using GLP-1 Rabbit mAb at a a dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining. High pressure antigen retrieval performed with 0.01M Citrate Buffer(pH 6.0) prior to IF staining.
IF-P
Immunofluorescence analysis of paraffin embedded Mouse pancreas using GLP-1 Rabbit mAb at a a dilution of 1:100 (40x lens). Secondary antibody: Cy3 conjugated Goat anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining. High pressure antigen retrieval performed with 0.01M Citrate Buffer(pH 6.0) prior to IF staining.| Application Notes | IHC:1:50-1:200 IF-P:1:50-1:200 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage Buffer | PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3. |
