This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
Alternative Names
ALOX5AP MK-886-binding protein
Molecular Weight(MW)
18 kDa
Cellular Localization
Endoplasmic reticulum,Membrane,Nucleus.
Application
WB
Western blot analysis of extracts from K562 cells using FLAP Rabbit mAb at 1:1000.
WB
Western blot analysis of extracts from THP-1,Pancl cells using FLAP Rabbit mAb at 1:500.
Application Notes
WB:1:1000-1:5000
Additional Information
Form
Liquid
Storage Instructions
Store at -20°C.Stable for 12 months from date of receipt.
Storage Buffer
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.