Jurkat cells were subjected to SDS PAGE followed by western blot with PCDHGB7 antibody at dilution of 1:2000 incubated at room temperature for 1.5 hours.
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
Alternative Names
ME6 PCDH GAMMA B7 PCDHGB7 Protocadherin gamma B7
Molecular Weight(MW)
105 kDa
Cellular Localization
Cell membrane,Membrane.
Application
WB
Jurkat cells were subjected to SDS PAGE followed by western blot with PCDHGB7 antibody at dilution of 1:2000 incubated at room temperature for 1.5 hours.
Application Notes
WB:1:1000-1:4000
Additional Information
Form
Liquid
Storage Instructions
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage.
Storage Buffer
PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.