WB
Various whole cell lysates were separated by 4-8% SDS-PAGE, and the membrane was blotted with anti-IGF-IIR antibody. The HRP-conjugated Goat anti-Rabbit IgG (H + L) antibody was used to detect the antibody.IHC
Mouse kidney was stained with anti-IGF-IIR Rabbit antibody.IHC
Human kidney was stained with anti-IGF-IIR Rabbit antibody.| Product Name | IGF-IIR Rabbit mAb |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG,K |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| WB:1:2000-1:10000 IHC:1:200-1:1000 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | IGF2R |
|---|---|
| Gene Synonyms | MPR1 MPRI CD222 CIMPR M6P-R MPR300 CI-M6PR MPR 300 M6P/IGF2R |
| Gene Full Name | insulin like growth factor 2 receptor |
| Gene Summary | This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015] |
| Alternative Names |
IGF2R MPRI Cation-independent mannose-6-phosphate receptor CI Man-6-P receptor CI-MPR M6PR 300 kDa mannose 6-phosphate receptor MPR 300 Insulin-like growth factor 2 receptor Insulin-like growth factor II receptor IGF-II receptor M6P/IGF2 receptor M6P/IGF2R CD222 |
| Molecular Weight(MW) | 274 kDa |
| Cellular Localization | Golgi apparatus membrane ; Single-pass type I membrane protein . Endosome membrane ; Single-pass type I membrane protein . Mainly localized in the Golgi at steady state and not detectable in lysosome (PubMed:18817523) . Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005) . . |
WB
Various whole cell lysates were separated by 4-8% SDS-PAGE, and the membrane was blotted with anti-IGF-IIR antibody. The HRP-conjugated Goat anti-Rabbit IgG (H + L) antibody was used to detect the antibody.
IHC
Mouse kidney was stained with anti-IGF-IIR Rabbit antibody.
IHC
Human kidney was stained with anti-IGF-IIR Rabbit antibody.| Application Notes | WB:1:2000-1:10000 IHC:1:200-1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | -15°C to -25°C/1 year (Do not lower than -25°C). |
| Storage Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA. |
