Recombinant Human Double homeobox protein 4 protein (217-402AA).
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHCWB
WB:1:500-1:5000 IHC:1:20-1:200
Species Reactivity
Human
Concentration
1mg/ml
Purification
Protein G
Target Information
Gene Symbol
DUX4
Gene Synonyms
DUX4L
Gene Full Name
double homeobox 4
Gene Summary
This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Alternative Names
DUX4 antibody DUX10Double homeobox protein 4 antibody Double homeobox protein 10 antibody