WB
Various whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-JAB1 antibody. The HRP-conjugated Goat anti-Rabbit IgG (H + L) antibody was used to detect the antibody.IHC
Mouse prostate was stained with anti-JAB1 Rabbit antibody.| Product Name | JAB1 Rabbit mAb |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG,K |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| WB:1:2000-1:10000 IHC:1:200-1:1000 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | COPS5 |
|---|---|
| Gene Synonyms | CSN5 JAB1 SGN5 MOV-34 |
| Gene Full Name | COP9 signalosome subunit 5 |
| Gene Summary | The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008] |
| Alternative Names |
COPS5 CSN5 JAB1 COP9 signalosome complex subunit 5 SGN5 Signalosome subunit 5 Jun activation domain-binding protein 1 |
| Molecular Weight(MW) | 38 kDa |
| Cellular Localization | Cytoplasm , cytosol . Nucleus . Cytoplasm , perinuclear region . Cytoplasmic vesicle , secretory vesicle , synaptic vesicle . Nuclear localization is diminished in the presence of IFIT3. |
| SwissProt ID | Q92905 |
|---|
WB
Various whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-JAB1 antibody. The HRP-conjugated Goat anti-Rabbit IgG (H + L) antibody was used to detect the antibody.
IHC
Mouse prostate was stained with anti-JAB1 Rabbit antibody.| Application Notes | WB:1:2000-1:10000 IHC:1:200-1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | -15°C to -25°C/1 year (Do not lower than -25°C). |
| Storage Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA. |
