| Gene Symbol |
ATF4
|
| Gene Synonyms |
CREB2
TXREB
CREB-2
TAXREB67 |
| Gene Full Name |
activating transcription factor 4 |
| Gene Summary |
This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011] |
| Molecular Weight(MW) |
39kDa(observed：50kDa) |
| Source |
Rabbit |
| Cellular Localization |
Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus |
