This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq, Jul 2008]
Alternative Names
3'exon32-5'exon37 member of the trx/MLL family histone-lysine N-methyltransferase 2B-like histone-lysine N-methyltransferase MLL4 KMT2D lysine (K)-specific methyltransferase 2B lysine N-methyltransferase 2B mixed lineage leukemia 2 mixed lineage leukemia gene homolog 2 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog Drosophila) 4 myeloid/lymphoid or mixed-lineage leukemia 4 myeloid/lymphoid or mixed-lineage leukemia protein 4 myeloid/lymphoid or mixed-lineage leukemia protein 4 homolog Proline-rich ligand for the WW domain of FBP11 trithorax homolog 2 trithorax homologue 2 WBP-7 WW domain binding protein 7