ATP-dependent helicase CHD3 CHD-3 chromo domain-containing protein 3 hZFH MGC40857 Mi 2a Mi-2 alpha mi-2 autoantigen 240 kDa protein Mi2 ALPHA Prp9 1 unnamed protein product zinc finger helicase zinc finger helicase-like zinc-finger helicase (Snf2-like)
Gene Full Name
chromodomain helicase DNA binding protein 3
Gene Summary
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]