DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of the antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2. [provided by RefSeq, Aug 2020]
Alternative Names
ATP-dependent RNA helicase DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 DEAD box protein 58 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide DEAD/H box helicase 58 DEAD/H box polypeptide RIG-I DExD/H-box helicase 58 probable ATP-dependent RNA helicase DDX58 retinoic acid-inducible gene 1 protein retinoic acid-inducible gene I protein retinoic acid-inducible gene-I RIG-1 RIG-I RIG-I-like receptor 1 RNA helicase RIG-I