| Product Name | RIG-I Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | RIG-1; Retinoic Acid-inducible Gene 1 Protein; DEAD-box Protein 58; Probable ATP-dependent RNA Helicase DDX58 |
| Product description | RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5’-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-I recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation. |
| Immunogen | Recombinant human RIG-I (aa 201-713). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | IHCIPWB |
| Immunohistochemistry: (paraffin sections). Immunoprecipitation: (1:200). Western blot: (1:1,000).: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | DDX58 |
|---|---|
| Alternative Names | RIG-1 Retinoic Acid-inducible Gene 1 Protein DEAD-box Protein 58 Probable ATP-dependent RNA Helicase DDX58 |
| Tissue Specificity | Recognizes human and mouse RIG-I. |
| Application Notes | Immunohistochemistry: (paraffin sections). Immunoprecipitation: (1:200). Western blot: (1:1,000).: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Stable for at least 1 year after receipt when stored at -20˚C. |
| Storage Buffer | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
