This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]
Alternative Names
21 kDa transmembrane trafficking protein 21 kDa transmembrane-trafficking protein integral membrane protein Tmp21-I (p23) ORF putative p24 family protein delta-1 p24delta p24delta1 testicular tissue protein Li 206 transmembrane emp24-like trafficking protein 10 transmembrane protein Tmp21 transmembrane trafficking protein transmembrane trafficking protein 21