This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Alternative Names
epididymis secretory sperm binding protein Li 51e GLY A+ glycine auxotroph A human complement for hamster glycine hydroxymethyltransferase mitochondrial serine hydroxymethyltransferase serine aldolase serine hydroxymethylase serine hydroxymethyltransferase 2 (mitochondrial) serine hydroxymethyltransferase 2 (mitochondrial) isoform SHMT2_1 serine hydroxymethyltransferase 2 (mitochondrial) isoform SHMT2_2 serine methylase SHMT 2 threonine aldolase