This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]
Alternative Names
bA535K18.1 FHL-1 FHL1 FHL1B formerly SLIM1 four-and-a-half Lin11 Isl-1 and Mec-3 domains 1 heart protein with four and a half LIM domains KYO-T LIM protein SLIMMER LIM protein rFHL1c MGC111107 RP11-535K18.1 skeletal and cardiac muscle SLIM isoform skeletal muscle LIM-protein 1