This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 infection. [provided by RefSeq, Sep 2020]
Alternative Names
10 kDa interferon gamma-induced protein C Cmotif chemokine C X C motif chemokine CC motif chemokine CCmotif chemokine chemokine (C-X-C motif) ligand 10 CXC CXC motif chemokine CXCL gamma IP10 gamma-IP10 H-IP-10 interferon activated gene 10 interferon-gamma induced protein CRG-2 interferon-inducible cytokine IP-10 M-IP-10 protein 10 from interferon (gamma)-induced cell line small inducible cytokine B subfamily (Cys-X-Cys) member 10 small inducible cytokine subfamily B (Cys-X-Cys) member 10 small-inducible cytokine B10