KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]
Alternative Names
GCN5 (general control of amino-acid synthesis yeast homolog)-like 2 GCN5 general control of amino acid synthesis-like 2 general control of amino acid synthesis 5-like 2 general control of amino acid synthesis protein 5-like 2 general control of amino acid synthesis yeast homolog-like 2 General control of amino acid synthesis yeast homolog-like 2 general control of amino acid synthesis-like 2 histone acetyltransferase GCN5 histone acetyltransferase GCN5 family histone glutaryltransferase KAT2A histone succinyltransferase KAT2A hsGCN5 K(lysine) acetyltransferase 2A KATA2 lysine acetyltransferase 2A PCAF-B/GCN5 protein lactyltransferase KAT2A STAF97
Molecular Weight(MW)
93kDa
Source
Rabbit
Cellular Localization
Nucleus;Chromosome;Cytoplasm, cytoskeleton, microtubule organizing center, centrosome