Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Alternative Names
3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 2 adenosine 5'-phosphosulfate kinase adenylyl-sulfate kinase ATP sulfurylase/adenosine 5'-phosphosulfate kinase ATP sulfurylase/APS kinase 2 ATPSK2 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 bifunctional enzyme epididymis secretory sperm binding protein PAPS synthase 2 PAPS synthase 2b b ATP sulfurylase/adenosine 5'-phosphosulfate kinase 2b PAPS synthetase 2 PAPS synthethase 2 SK 2 sulfate adenylyltransferase