This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
Alternative Names
h KIAA1047 hCIT529I10 MGC104216 N-CoR N-Cor/SMRT corepressor Rip13 N-CoR1 NCoR nrcr nuclear receptor corepressor protein phosphatase 1 regulatory subunit 109 putative retinoid X receptor-interacting protein 13 thyroid hormone- and retinoic acid receptor-associated corepressor 1