Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]
Alternative Names
a frameshift between exon 1 (0.18) and exon 2 changed the ORF of p16INK4 gene. alternative reading frame autophagy inducer CDK4 inhibitor p16-INK4 CDK4I CDKN2A/ARF Intron 2 lncRNA cell cycle inhibitor cell cycle negative regulator beta cell cycle regulator Cyclin dependent kinase inhibitor 2A (p16 inhibits CDK4) cyclin-dependent kinase 4 inhibitor A cyclin-dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4) cyclin-dependent kinase inhibitor 2A (p16 inhibits CDK4) cyclin-dependent kinase inhibitor 2A (p16 inhibits CDK4) alternatively spliced cyclin-dependent kinase inhibitor 2a p16Ink4a cyclin-dependent kinase inhibitor 2a p19Arf cyclin-dependent kinase inhibitor protein hypothetical 18.1 kDa protein from longest open reading frame inhibitor of cdk4 A mitochondrial smARF multiple tumor suppressor 1 multiple tumour suppressor 1 p16 p16 gamma p16-INK4 p16-INK4a p16ink4a