LMOR M-OR-1 MOP MOP-R MOR MOR-1 MOR-1O MOR1 MORA muOR OPRM Oprrm1
Gene Full Name
opioid receptor mu 1
Gene Summary
This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]
Alternative Names
exon 1 splice variant exon 4 splice variant G-protein coupled receptor GPCR GPCR MOR-1K1 hMOP KIAA0403 M-OR-1 MOP receptor MOR-1 MOR-1A MOR-1BI MOR-1BII MOR-1C MOR-1CII alternatively spliced MOR-1Eiii MOR-1Eiv MOR-1F MOR-1P MOR-1Q MOR-1R MOR-1T MOR-1U MOR1 MOR3 Mu class opiate receptor mu opiate receptor mu opioid receptor hMOR-1a mu opioid receptor MOR-1BI mu opioid receptor MOR-1P MUOR1 Opioid mu receptor Opioid Receptor opioid receptor B OTTHUMP00000017463 rMOR-1G2 rMOR-1H2 rMOR-1I2