| Product Name | Anti-CYP2D6 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISA |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | CYP2D6 |
|---|---|
| Gene Synonyms | cholesterol 25-hydroxylase CYP2D6 CYPIID18 CYPIID3 CYPIID4 cytochrome P-450 IID3 cytochrome P450 cytochrome P450 2D-29 cytochrome P450 2D-35 cytochrome P450 2d18 cytochrome P450, family 2, subfamily d, polypeptide 13 cytochrome P450, family 2, subfamily d, polypeptide 22 cytochrome P450, family 2, subfamily D, polypeptide 6 cytochrome P450, subfamily 2D, polypeptide 6 cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6 cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1 cytochrome P450, subfamily IID, polypeptide 6 Cytochrome P450, subfamily IID3 Cytochrome P450, subfamily IID4 cytochrome P450-CMF3 cytochrome P450-DB1 cytochrome P450-DB3 cytochrome P450-DB4 debrisoquine 4-hydroxylase flavoprotein-linked monooxygenase microsomal monooxygenase nonfunctional cytochrome P450 2D6 P450 2D-29/2D-35 P450-CMF3 P450-DB3 P450-DB4 xenobiotic monooxygenase |
| Gene Full Name | cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene) |
| Gene Summary | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] |
| Alternative Names | CPD6 CYP2D Cyp2d13 Cyp2d18 Cyp2d22 Cyp2d4v1 Cyp2d4v2 Cyp2d6 CYP2D7AP CYP2D7BP CYP2D7P2 CYP2D8P2 CYP2DL1 CYPIID6 P450-DB1 P450C2D P450DB1 |
| Molecular Weight(MW) | 55kDa |
| Source | Rabbit |
| Cellular Localization | Endoplasmic reticulum membrane ;Microsome membrane |
| SwissProt ID | P10635 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300. |
