| Gene Symbol |
IL3RA
|
| Gene Synonyms |
CD123 antigen IL-3 receptor subunit alpha IL-3R subunit alpha interleukin 3 receptor, alpha (low affinity) membrane protein |
| Gene Full Name |
interleukin 3 receptor subunit alpha |
| Gene Summary |
The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012] |
| Alternative Names |
CD123 antigen IL-3 receptor subunit alpha IL-3R subunit alpha interleukin 3 receptor alpha (low affinity) membrane protein |
| Molecular Weight(MW) |
43kDa |
| Source |
Rabbit |
| Cellular Localization |
Cell membrane |