| Gene Symbol |
Afdn
|
| Gene Synonyms |
AF6 Af-6 Gm314 Mllt4 Afadin I-afadin S-afadin 5033403D15Rik |
| Gene Full Name |
afadin, adherens junction formation factor |
| Gene Summary |
Enables cell adhesion molecule binding activity. Involved in several processes, including cell-cell adhesion mediated by cadherin; pore complex assembly; and regulation of postsynapse assembly. Acts upstream of or within several processes, including adherens junction maintenance; nervous system development; and regulation of oligodendrocyte progenitor proliferation. Located in several cellular components, including adherens junction; apical junction complex; and apical part of cell. Part of pore complex. Is active in hippocampal mossy fiber to CA3 synapse; postsynaptic density membrane; and presynaptic active zone membrane. Is expressed in several structures, including central nervous system; embryo ectoderm; eye; genitourinary system; and tail bud. Orthologous to human AFDN (afadin, adherens junction formation factor). [provided by Alliance of Genome Resources, Jul 2025] |
| Alternative Names |
AF6
AFAD_HUMAN
Afadin
ALL1-fused gene from chromosome 6 protein
Mllt4
Protein Af-6
Protein AF6 |
| Molecular Weight(MW) |
207 kDa |
| Cellular Localization |
Cell junction>Adherens junction. |