| Product Name | Anti-Phospho-MKK3 (Ser189) antibody(Ser218) |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Ser189/Ser218 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | MAP2K3 |
|---|---|
| Gene Synonyms | MEK3 MKK3 MAPKK3 PRKMK3 SAPKK2 SAPKK-2 |
| Gene Full Name | mitogen-activated protein kinase kinase 3 |
| Gene Summary | The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008] |
| Alternative Names | AW212142 dual specificity mitogen activated protein kinase kinase 3 Dual specificity mitogen-activated protein kinase kinase 3 MAP kinase kinase 3 map2k3 MAPK ERK kinase 3 MAPK/ERK kinase 3 MAPKK 3 MAPKK3 MEK 3 MEK3 Mitogen activated protein kinase kinase 3 MKK 3 MKK3 mMKK3b MP2K3_HUMAN PRKMK 3 PRKMK3 protein kinase mitogen-activated kinase 3 SAPK kinase 2 SAPKK 2 SAPKK2 Stress activated protein kinase kinase 2 |
| Molecular Weight(MW) | 39 kDa |
| Cellular Localization | Cytoplasm, Cytosol, Membrane, Nucleoplasm. |
| SwissProt ID | P46734 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
