| Product Name | Anti-Phospho-Kir6.2 (Thr224) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Thr224 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | KCNJ11 |
|---|---|
| Gene Synonyms | BIR HHF2 PHHI IKATP PNDM2 TNDM3 KIR6.2 MODY13 |
| Gene Full Name | potassium inwardly rectifying channel subfamily J member 11 |
| Gene Summary | Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009] |
| Alternative Names | ATP sensitive inward rectifier potassium channel 11 Beta cell inward rectifier subunit BIR HHF 2 HHF2 IKATP Inward rectifier K(+) channel Kir6.2 Inwardly rectifying potassium channel KIR6.2 IRK 11 IRK11 KCNJ11 Kir 6.2 Kir6.2 MGC133230 PHHI Potassium channel inwardly rectifing subfamily J member 11 Potassium channel inwardly rectifying subfamily J member 11 Potassium inwardly rectifying channel J11 TNDM 3 TNDM3 |
| Molecular Weight(MW) | 44 kDa |
| Cellular Localization | Membrane. |
| SwissProt ID | Q14654 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
