| Product Name | Anti-Phospho-UHRF1 (Ser311) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Ser311 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | UHRF1 |
|---|---|
| Gene Synonyms | Np95 hNP95 ICBP90 RNF106 TDRD22 hUHRF1 huNp95 |
| Gene Full Name | ubiquitin like with PHD and ring finger domains 1 |
| Gene Summary | This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014] |
| Alternative Names | Ac2-121 AL022808 E3 ubiquitin-protein ligase UHRF1 EC 6.3.2.- FLJ21925 hNP95 hUHRF1 HuNp95 ICBP90 Inverted CCAAT box binding protein of 90 kDa Inverted CCAAT box binding protein 90-kD Inverted CCAAT box-binding protein of 90 kDa Liver regeneration-related protein LRRG126 MGC138707 NP95 Nuclear phosphoprotein 95 Nuclear phosphoprotein 95-KD Nuclear protein 95 Nuclear zinc finger protein Np95 RING finger protein 106 RNF106 TDRD22 Transcription factor ICBP90 Ubiquitin like containing PHD and RING finger domains protein 1 Ubiquitin like PHD and RING finger domain containing protein 1 Ubiquitin-like PHD and RING finger domain-containing protein 1 Ubiquitin-like protein containing PHD and RING finger domains 1 Ubiquitin-like with PHD and ring finger domains 1 Ubiquitin-like containing PHD and RING finger domains 1 Ubiquitin-like-containing PHD and RING finger domains protein 1 UHRF1 UHRF1_HUMAN |
| Molecular Weight(MW) | 90 kDa |
| Cellular Localization | Chromosome,Nucleus. |
| SwissProt ID | Q96T88 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
