| Product Name | Anti-Phospho-PYK2 (Tyr881) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Tyr881 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PTK2B |
|---|---|
| Gene Synonyms | PKB PTK CAKB FAK2 PYK2 CADTK FADK2 RAFTK |
| Gene Full Name | protein tyrosine kinase 2 beta |
| Gene Summary | This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Alternative Names | CADTK CAK-beta CAKB CAKbeta Calcium regulated non receptor proline rich tyrosine kinase Calcium-dependent tyrosine kinase Cell adhesion kinase beta E430023O05Rik EC 2.7.10.2 FADK 2 FADK2 FAK2 FAK2_HUMAN Focal adhesion kinase 2 MGC124628 PKB Proline-rich tyrosine kinase 2 Protein kinase B Protein Tyrosine Kinase 2 Beta Protein-tyrosine kinase 2-beta PTK PTK2B PTK2B protein tyrosine kinase 2 beta PYK2 RAFTK RAFTK2 Related adhesion focal tyrosine kinase |
| Molecular Weight(MW) | 116 kDa |
| Cellular Localization | Cell junction,Cell membrane,Cell projection,Cytoplasm,Membrane,Nucleus. |
| SwissProt ID | Q14289 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
