| Gene Symbol |
SLC6A4
|
| Gene Synonyms |
HTT 5HTT OCD1 SERT 5-HTT SERT1 hSERT 5-HTTLPR |
| Gene Full Name |
solute carrier family 6 member 4 |
| Gene Summary |
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression. [provided by RefSeq, May 2019] |
| Alternative Names |
5 HTT 5 HTTLPR 5 hydroxytryptamine (serotonin) transporter 5 hydroxytryptamine transporter 5HT transporter 5HTT hSERT HTT Na+/Cl- dependent serotonin transporter OCD1 SC6A4_HUMAN Serotonin transporter 1 SERT SERT1 Slc6a4 Sodium dependent serotonin transporter Sodium-dependent serotonin transporter Solute carrier family 6 (neurotransmitter transporter) member 4 solute carrier family 6 (neurotransmitter transporter serotonin) member 4 Solute carrier family 6 member 4 |
| Molecular Weight(MW) |
70 kDa |
| Cellular Localization |
Cell junction,Cell membrane,Cell projection,Endosome,Membrane,Synapse. |