| Product Name | Anti-Phospho-GluR2 (Ser843) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Ser843 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | GRIA2 |
|---|---|
| Gene Synonyms | GLUR2 GLURB GluA2 HBGR2 NEDLIB gluR-2 gluR-B GluR-K2 |
| Gene Full Name | glutamate ionotropic receptor AMPA type subunit 2 |
| Gene Summary | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008] |
| Alternative Names | AMPA 2 AMPA selective glutamate receptor 2 AMPA-selective glutamate receptor 2 AMPA2 GluA2 GLUR 2 GLUR B GluR K2 GluR-2 GluR-B GluR-K2 GLUR2 GLURB Glutamate receptor 2 Glutamate receptor ionotropic AMPA 2 Glutamate receptor ionotropic Gria2 GRIA2_HUMAN HBGR2 |
| Molecular Weight(MW) | 99 kDa |
| Cellular Localization | Cell membrane,Membrane,Postsynaptic cell membrane,Synapse. |
| SwissProt ID | P42262 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
