| Product Name | Anti-Phospho-Bub1 (Ser459) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Ser459 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | BUB1 |
|---|---|
| Gene Synonyms | BUB1A BUB1L hBUB1 MCPH30 |
| Gene Full Name | BUB1 mitotic checkpoint serine/threonine kinase |
| Gene Summary | This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| Alternative Names | Bub1 BUB1 budding uninhibited by benzimidazoles 1 homolog BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) BUB1 mitotic checkpoint serine/threonine kinase BUB1 S. cerevisiae homolog of BUB1_HUMAN BUB1A BUB1L Budding uninhibited by benzimidazoles 1 (yeast homolog) Budding uninhibited by benzimidazoles 1 homolog Budding uninhibited by benzimidazoles 1 S. cerevisiae homolog of hBUB1 Homolog of mitotic checkpoint gene BUB1 Mitotic checkpoint gene BUB1 Mitotic checkpoint serine/threonine protein kinase BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 Mitotic spindle checkpoint kinase Putative serine/threonine protein kinase |
| Molecular Weight(MW) | 122 kDa |
| Cellular Localization | Nucleus, kinetochore. |
| SwissProt ID | O43683 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
