| Product Name | Anti-Phospho-GIRK1/KIR3.1/KCNJ3 (Ser185) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Ser185 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | KCNJ3 |
|---|---|
| Gene Synonyms | KGA GIRK1 KIR3.1 |
| Gene Full Name | potassium inwardly rectifying channel subfamily J member 3 |
| Gene Summary | Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, May 2012] |
| Alternative Names | G protein activated inward rectifier potassium channel 1 G protein-activated inward rectifier potassium channel 1 GIRK-1 GIRK1 Inward rectifier K(+) channel Kir3.1 Inwardly rectifying potassium channel KIR3.1 inwardly rectifying subfamily J member 3 IRK3 IRK3_HUMAN Kcnf3 Kcnj3 KGA KGB1 Kir3.1 Potassium channel Potassium channel inwardly rectifying subfamily J member 3 Potassium inwardly-rectifying channel subfamily J member 3 |
| Molecular Weight(MW) | 57 kDa |
| Cellular Localization | Membrane |
| SwissProt ID | P48549 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
