| Gene Symbol |
NEDD4
|
| Gene Synonyms |
RPF1 NEDD4-1 |
| Gene Full Name |
NEDD4 E3 ubiquitin protein ligase |
| Gene Summary |
This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016] |
| Alternative Names |
Cell proliferation-inducing gene 53 protein E3 ubiquitin protein ligase Nedd4 E3 ubiquitin-protein ligase NEDD4 HECT-type E3 ubiquitin transferase NEDD4 KIAA0093 NEDD 4 NEDD-4 Nedd4 NEDD4_HUMAN Neural precursor cell expressed developmentally down regulated 4 Neural precursor cell expressed developmentally down-regulated protein 4 neural precursor cell expressed developmentally down-regulated 4 E3 ubiquitin protein ligase PIG53 receptor-potentiating factor 1 RPF1 |
| Molecular Weight(MW) |
149 kDa |
| Cellular Localization |
Cell membrane,Cytoplasm,Membrane,Nucleus. |