| Gene Symbol |
SMARCA4
|
| Gene Synonyms |
BRG1 CSS4 SNF2 SWI2 MRD16 RTPS2 BAF190 OTSC12 SNF2L4 SNF2LB hSNF2b BAF190A SNF2-beta |
| Gene Full Name |
SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 |
| Gene Summary |
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] |
| Alternative Names |
ATP dependent helicase SMARCA4 ATP-dependent helicase SMARCA4 BAF 190 BAF190 BAF190A Brahma protein like 1 BRG1 BRG1 associated factor 190A BRG1 protein BRG1-associated factor 190A BRM/SWI2 related gene 1 Global transcription activator homologous sequence global transcription activator snf2l4 Homeotic gene regulator hSNF2b Mitotic growth and transcription activator MRD16 Nuclear protein GRB1 Protein brahma homolog 1 Protein BRG-1 Protein BRG1 RTPS2 SMARC A4 SMARCA4 SMCA4_HUMAN SNF2 SNF2 beta SNF2 like 4 SNF2-beta SNF2B SNF2L4 SNF2LB Sucrose nonfermenting like 4 SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 4 SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a member 4 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 SWI2 Transcription activator BRG1 |
| Molecular Weight(MW) |
185 kDa |
| Cellular Localization |
Nucleus. |