| Product Name | Anti-Phospho-CAD (Ser1859) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Ser1859 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CAD |
|---|---|
| Gene Synonyms | CDG1Z DEE50 GATD4 EIEE50 |
| Gene Full Name | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase |
| Gene Summary | The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015 |
| Alternative Names | Aspartate carbamoyltransferase Aspartate transcarbamylase CAD protein CAD trifunctional protein Carbamoyl phosphate synthetase 2 CPSase ATCase DHOase Dihydroorotase Glutamine dependent carbamoyl phosphate synthase Multifunctional protein CAD |
| Molecular Weight(MW) | 243 kDa |
| Cellular Localization | Cytoplasm, Nucleus. |
| SwissProt ID | P27708 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
