| Product Name | Anti-Phospho-Smad7 (Ser249) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Ser249 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | SMAD7 |
|---|---|
| Gene Synonyms | CRCS3 MADH7 MADH8 |
| Gene Full Name | SMAD family member 7 |
| Gene Summary | The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
| Alternative Names | CRCS3 FLJ16482 hSMAD 7 hSMAD7 MAD (mothers against decapentaplegic Drosophila) homolog 7 MAD Mad homolog 7 MAD homolog 8 MAD mothers against decapentaplegic homolog 7 MADH 7 MADH 8 MADH6 MADH7 MADH8 Mothers Against Decapentaplegic Drosophila Homolog of 6 Mothers Against Decapentaplegic Drosophila Homolog of 7 Mothers against decapentaplegic homolog 7 Mothers against decapentaplegic homolog 8 Mothers against DPP homolog 7 Mothers against DPP homolog 8 SMA- AND MAD-RELATED PROTEIN 7 SMAD 7 SMAD SMAD family member 7 SMAD mothers against DPP homolog 7 (Drosophila) SMAD mothers against DPP homolog 7 SMAD6 Smad7 SMAD7_HUMAN |
| Molecular Weight(MW) | 46 kDa |
| Cellular Localization | Cytoplasm, Nucleus. |
| SwissProt ID | O15105 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
