| Gene Symbol |
NFATC2
|
| Gene Synonyms |
JCOSL NFAT1 NFATP |
| Gene Full Name |
nuclear factor of activated T cells 2 |
| Gene Summary |
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012] |
| Alternative Names |
AI607462 cytoplasmic 2 KIAA0611 NF ATc2 NF ATp NF-ATc2 NF-ATp NFAC2_HUMAN NFAT 1 NFAT pre existing subunit NFAT pre-existing subunit NFAT transcription complex preexisting component NFAT1 NFAT1-D NFATc2 NFATp Nuclear factor of activated T cells cytoplasmic 2 Nuclear factor of activated T cells cytoplasmic calcineurin dependent 2 Nuclear factor of activated T cells pre-existing component Nuclear factor of activated T cells preexisting component Nuclear factor of activated T-cells Preexisting nuclear factor of activated T cells 2 T cell transcription factor NFAT 1 T-cell transcription factor NFAT1 |
| Molecular Weight(MW) |
100 kDa |
| Cellular Localization |
Cytoplasm, Nucleus. |