| Gene Symbol |
MERTK/TYRO3
|
| Gene Synonyms |
MER RP38 c-Eyk c-mer Tyro12 BYK Dtk RSE Rek Sky Tif Etk-2 |
| Gene Full Name |
MER proto-oncogene, tyrosine kinase/TYRO3 protein tyrosine kinase |
| Gene Summary |
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]/The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010] |
| Alternative Names |
Brt BYK DTK Etk-2 protein tyrosine kinase 3 Rek RSE SKY Tif tyro3 TYRO3 protein tyrosine kinase TYRO3_HUMAN Tyrosine-protein kinase byk Tyrosine-protein kinase DTK Tyrosine-protein kinase receptor TYRO3 Tyrosine-protein kinase RSE Tyrosine-protein kinase SKY Tyrosine-protein kinase TIF c MER c mer proto oncogene tyrosine kinase c-mer cMER cmer protooncogene tyrosine kinase Eyk MER MER receptor tyrosine kinase MERK MERPEN Mertk MERTK c-mer proto-oncogene tyrosine kinase MERTK_HUMAN MGC133349 nmf12 Nyk Proto oncogene tyrosine protein kinase MER Proto oncogene tyrosine protein kinase MER precursor Proto-oncogene c-Mer Receptor tyrosine kinase MerTK RP38 STK kinase Tyrosine-protein kinase Mer |
| Molecular Weight(MW) |
110 kDa/97 kDa |
| Cellular Localization |
Cell membrane. |