| Product Name | Anti-Phospho-BRCA2 (Ser3291) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Ser3291 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | BRCA2 |
|---|---|
| Gene Synonyms | FAD FACD FAD1 GLM3 BRCC2 FANCD PNCA2 FANCD1 XRCC11 BROVCA2 |
| Gene Full Name | BRCA2 DNA repair associated |
| Gene Summary | The product of this gene in involved in maintenance of genome stability. It is involved in double-strand break repair pathways during mitotic and meiotic homologous recombination and functions in protecting DNA replication forks. The encoded protein contains sites for interactions with PALB2 and EMSY and an N-terminal DNA binding domain. It also contains a RAD51 binding domain with multiple components. It has multiple BRC repeats, an alpha helix domain, oligonucleotide binding folds, and a tower-like domain. It has a nuclear localization signal and a phosphorylation site for cyclin-dependent kinase. The C-terminus of the protein can bind single-stranded and double-stranded DNA. The product of this gene interacts with multiple proteins, including RAD51. It is involved in recruiting RAD51 filaments to DNA double-strand break sites and also in cytoplasmic division. It also acts as a tumor suppressor. Mutations in this gene or decreased expression have been implicated in multiple tumor types, including breast, ovarian, pancreatic, prostate and other cancers. [provided by RefSeq, May 2026] |
| Alternative Names | BRCA 2 BRCA1/BRCA2 containing complex subunit 2 Brca2 BRCA2 DNA repair associated BRCA2_HUMAN BRCC 2 BRCC2 Breast and ovarian cancer susceptibility gene early onset breast and ovarian cancer susceptibility protein 2 Breast cancer 2 early onset Breast Cancer 2 tumor suppressor Breast cancer susceptibility protein BRCA2 Breast cancer type 2 susceptibility protein BROVCA2 FACD FAD 1 FAD FAD1 FANCB FANCD 1 FANCD FANCD1 FANCD1 gene Fanconi anemia complementation group D1 Fanconi anemia group D1 protein GLM3 mutant BRCA2 OTTHUMP00000018803 OTTHUMP00000042401 PNCA2 XRCC11 |
| Molecular Weight(MW) | 384 kDa |
| Cellular Localization | Chromosome, Cytoplasm, Cytoskeleton, Nucleus, Telomere. |
| SwissProt ID | P51587 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
