| Product Name | Anti-Phospho-FADD (Ser190) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Ser190 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | FADD |
|---|---|
| Gene Synonyms | GIG3 IMD90 MORT1 |
| Gene Full Name | Fas associated via death domain |
| Gene Summary | The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008] |
| Alternative Names | FADD FADD protein FADD_HUMAN Fas (TNFRSF6) associated via death domain Fas associated via death domain Fas associating death domain containing protein Fas associating protein Fas associating protein with death domain Fas TNFRSF6 associated via death domain FAS-associated death domain protein FAS-associating death domain-containing protein GIG 3 GIG3 Growth inhibiting gene 3 protein Growth-inhibiting gene 3 protein H sapiens mRNA for mediator of receptor induced toxicity Mediator of receptor induced toxicity MGC8528 MORT 1 MORT1 Protein FADD |
| Molecular Weight(MW) | 23 kDa |
| Cellular Localization | Cytoplasm. |
| SwissProt ID | Q13158 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
