| Product Name | Anti-Phospho-MYPT1 (Tyr766) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Tyr766 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PPP1R12A |
|---|---|
| Gene Synonyms | MBS GUBS M130 MYPT1 |
| Gene Full Name | protein phosphatase 1 regulatory subunit 12A |
| Gene Summary | Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009] |
| Alternative Names | M130 MBS Myosin binding subunit Myosin phosphatase target subunit 1 Myosin phosphatase targeting subunit 1 Myosin phosphatase-targeting subunit 1 MYPT1 MYPT1_HUMAN PPP1R12A Protein phosphatase 1 regulatory inhibitor subunit 12A Protein phosphatase 1 regulatory subunit 12A Protein phosphatase 1 regulatory (inhibitor) subunit 12A Protein phosphatase myosin binding subunit Protein phosphatase myosin-binding subunit |
| Molecular Weight(MW) | 115 kDa |
| Cellular Localization | Cytoplasm,Cytoskeleton. |
| SwissProt ID | O14974 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
