| Gene Symbol |
PAK3
|
| Gene Synonyms |
ARA bPAK MRX30 MRX47 OPHN3 PAK-3 XLID30 PAK3beta beta-PAK |
| Gene Full Name |
p21 (RAC1) activated kinase 3 |
| Gene Summary |
The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2017] |
| Alternative Names |
Alpha PAK Beta PAK bPAK CDKN1A Gamma PAK hPAK3 MRX30 MRX47 Oligophrenin 3 OPHN3 P21 (CDKN1A) activated kinase 2 P21 (CDKN1A) activated kinase 3 p21 activated kinase 1 p21 activated kinase 2 p21 activated kinase 3 P21 protein (Cdc42/Rac) activated kinase 1 P21 protein (Cdc42/Rac) activated kinase 2 P21 protein (Cdc42/Rac) activated kinase 3 P21/Cdc42/Rac1 activated kinase 1 (STE20 homolog yeast) P21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related) P58 P65 PAK PAK 2 PAK 3 PAK1 PAK2 PAK3 PAK3beta PAK65 PAKalpha PAKgamma S6/H4 kinase Serine/threonine protein kinase PAK 1 Serine/threonine protein kinase PAK 2 Serine/threonine protein kinase PAK 3 Serine/threonine protein kinase PAK1 Serine/threonine protein kinase PAK2 Serine/threonine protein kinase PAK3 STE20 homolog yeast |
| Molecular Weight(MW) |
62 kDa |
| Cellular Localization |
Cytoplasm. |