| Product Name | Anti-Phospho-RAD17 (Ser86) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Ser86 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | RAD17 |
|---|---|
| Gene Synonyms | CCYC R24L RAD24 HRAD17 RAD17SP |
| Gene Full Name | RAD17 checkpoint clamp loader component |
| Gene Summary | The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013] |
| Alternative Names | CCYC Cell cycle checkpoint protein Cell cycle checkpoint protein RAD17 FLJ41520 HRAD 17 hRad17 R24L Rad 17 Rad 24 RAD1 (S. pombe) homolog RAD1 homolog RAD17 RAD17 homolog (S. pombe) RAD17 homolog Rad17 like protein RAD17 S. pombe homolog of RAD17_HUMAN RAD17Sp Rad24 Rad24 mouse homolog of Rad24 S. cerevisiae homolog of RF C activator 1 homolog RF C/activator 1 homolog RF-C/activator 1 homolog |
| Molecular Weight(MW) | 77 kDa |
| Cellular Localization | Chromosome,Nucleus. |
| SwissProt ID | O75943 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
