| Product Name | Anti-Phospho-Lamin A/C (Ser390) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Ser390 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | LMNA |
|---|---|
| Gene Synonyms | FPL IDC LFP CDDC EMD2 FPLD HGPS LDP1 LMN1 LMNC MADA PRO1 CDCD1 CMD1A FPLD2 LMNL1 CMT2B1 LGMD1B |
| Gene Full Name | lamin A/C |
| Gene Summary | The protein encoded by this gene is part of the nuclear lamina, a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, May 2022] |
| Alternative Names | 70 kDa lamin Cardiomyopathy dilated 1A (autosomal dominant) CDCD1 CDDC CMD1A CMT2B1 EMD2 FPL FPLD FPLD2 HGPS IDC Lamin A Lamin A/C Lamin A/C like 1 Lamin Lamin C Lamin-A/C LDP1 LFP LGMD1B Limb girdle muscular dystrophy 1B (autosomal dominant) LMN 1 LMN A LMN C LMN1 LMNA LMNA_HUMAN LMNC LMNL1 Prelamin A/C PRO1 Renal carcinoma antigen NY REN 32 Renal carcinoma antigen NY-REN-32 Renal carcinoma antigen NYREN32 |
| Molecular Weight(MW) | 74 kDa |
| Cellular Localization | Intermediate filament, Nucleus. |
| SwissProt ID | P02545 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
