| Gene Symbol |
COX4I1
|
| Gene Synonyms |
COX4 COXIV COX4-1 COXIV-1 MC4DN16 COX IV-1 |
| Gene Full Name |
cytochrome c oxidase subunit 4I1 |
| Gene Summary |
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] |
| Alternative Names |
AL024441 COX 4 COX IV 1 COX IV COX IV-1 Cox4 COX41_HUMAN Cox4a COX4B COX4I1 COX4I2 COX4L2 COXIV Cytochrome c oxidase polypeptide IV Cytochrome c oxidase subunit 4 isoform 1 mitochondrial Cytochrome c oxidase subunit 4 isoform 1 mitochondrial Cytochrome C Oxidase subunit IV Cytochrome c oxidase subunit IV isoform 1 Cytochrome c oxidase subunit IV isoform 2 (lung) Cytochrome c oxydase subunit 4 dJ857M17.2 MGC105470 MGC72016 |
| Molecular Weight(MW) |
20 kDa |
| Cellular Localization |
Membrane, Mitochondrion, Mitochondrion inner membrane. |