| Gene Symbol |
OCLN
|
| Gene Synonyms |
BLCPMG PTORCH1 PPP1R115 |
| Gene Full Name |
occludin |
| Gene Summary |
This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011] |
| Alternative Names |
BLCPMG FLJ08163 FLJ18079 FLJ77961 FLJ94056 MGC34277 Occludin Ocln OCLN_HUMAN Tight junction protein occludin |
| Molecular Weight(MW) |
59 kDa |
| Cellular Localization |
Cell membrane, Cell junction, tight junction. |