Monoclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 (CEACAM1)
Antibody Type
Primary Antibodies
Immunogen
RPC977Hu01-Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 (CEACAM1)
Key Feature
Clonality
Monoclonal
Isotype
IgG1Kappa
Host Species
Mouse
Tested Applications
WB
WB: 0.01-2µg/mL
Species Reactivity
Human
Concentration
1mg/ml
Purification
Protein A/G
Target Information
Gene Symbol
CEACAM1
Gene Synonyms
BGP,BGP1,BGPI
Gene Full Name
CEA cell adhesion molecule 1
Gene Summary
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]
Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.