| Product Name | Mouse Cdkn2a Recombinant protein |
|---|---|
| Species Reactivity | Human |
| Gene Symbol | Cdkn2a |
| Gene Synonyms | Arf p16 MTS1 Pctr1 p19ARF p16INK4a p19 ARF-INK4a INK4a-ARF Ink4a/Arf p16(INK4a) |
| Gene Full Name | cyclin dependent kinase inhibitor 2A |
| Gene Summary | Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; MDM2/MDM4 family protein binding activity; and enzyme inhibitor activity. Involved in several processes, including negative regulation of lymphocyte proliferation; positive regulation of apoptotic process; and regulation of intracellular signal transduction. Acts upstream of or within several processes, including keratinocyte proliferation; negative regulation of mammary gland epithelial cell proliferation; and negative regulation of protein metabolic process. Located in cytoplasm and granular component. Part of protein-containing complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; immune system; and umbilical artery. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); melanoma (multiple); and pancreatic cancer (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A). |
